What is the case with people who are living as natural flesh

They cannot please God. The person who is occupied with material survival, with material happiness, with working, playing, eating, sleeping, reproducing is little different from an animal. He is not learning to become a son of God, which is the intended destiny of each believer in Christ.

God has predestined us to be changed into the image of His Son—Christ. If we ignore God’s plan for us, choosing instead to occupy ourselves with the human activities of the world, we are not fulfilling God’s purpose in calling us in Christ. If we continue to turn our back on God’s will for us our end will be tragic indeed when compared with the glory that the Lord had prepared for us.

For whom he did foreknow, he also did predestinate to be changed into the image of his Son, that he might be the firstborn among many brothers (Romans 8:29).