It has made him love sin & hate God

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As no heart can sufficiently conceive, so no tongue can adequately express—the state of wretchedness and ruin into which sin has cast guilty, miserable man! In separating him from God, sin severed him from the only source of all happiness and holiness. Sin has ruined him body and soul.

It has filled the body with sickness and disease! It has defaced and destroyed the image of God in the soul. It has made him love sin and hate God.